Graphics wise I would reckon that we will end up having varying levels of detail for the terrain so that it could run on lower end cards and shine on higher end. For example a lower end card by only be able to have the terrain tiles as 256x256 and dropping to 128x128 as you zoom out or whatever the values end up being. A high end card would be able to use 512x512 for every tile visible.
Then we have anistropic filtering and AA if we ever see any corners. Anti-Aliasing for textures could be an option too. Obviously these would be disabled for low end systems.
For sound I would reckon we could have a choice between software and hardware, maybe a limit to the amount of sounds playable at once? Really not that big a deal as even a soundblaster Pro can play 64 sounds at once I believe. Probably far more then we'll ever need.
As for keys/mouse like you said they'll become apparent as we go on. I'd like to see keyboard shortcuts for pretty much every action possible for hardcore players
" There's nothing like a bit of destiny to get the ball rolling " - Terry Pratchett - The Wyrd Sisters